Neutrophils and neutrophil serine proteases (NSPs) normally help protect the lungs from harm, but in bronchiectasis they can contribute to inflammation and lung destruction.^1-6

Too many neutrophils releasing an excess of NSPs can cause inflammation—a key component of bronchiectasis with limited treatment options. This neutrophilic inflammation can lead to devastating consequences, including increased exacerbation frequency and disease progression.^2,5-7